Pentamidine isethionate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pentamidine isethionate 是一种抗菌剂，用于预防和治疗耶氏肺孢子虫引起的肺孢子虫肺炎 (PCP)。

Pentamidine isethionate is an antimicrobial agent for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.(In Vitro):Pentamidine (0-10 μg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner.The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein.(In Vivo):Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice.

Cell Viability AssayCell Line:WM9, DU145, C4-2, Hey, WM480, and A549 cells Concentration:0-10 μg/mL Incubation Time:6 days Result:The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 μg/mL.

Animal Model:Athymic nude mice (6 weeks old) injected with WM9 cellsDosage:0.25 mg/mouse Administration:Intramuscular injection; every 2 days; for 4 weeks Result:Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.

Pentamidine Isethionate | Pentamidine isethionate salt | Pentamidine diisethionate

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Infection

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140-64-7

592.68

C23H36N4O10S2

>98% (HPLC)

DMSO: 100mg/ml(168.73 mM);Water: 100mg/ml(168.73 mM);Ethanol: <1mg/ml

C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O

4,4'-(Pentamethylenedioxy)-dibenzamidine bis(2-hydroxyethanesulfonate)4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid

(-20℃)

With Ice Pack

≥ 2 years